| Bioactivity | BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death[1]. |
| Invitro | BRD1991(20 μM, 24 h)在 HeLa/GFP-LC3 细胞中可以诱导完全的自噬通量，表现出轻微的细胞毒性，并随着时间的推移逐渐在细胞内积累[1]。 |
| Name | BRD1991 |
| CAS | 2235468-02-5 |
| Formula | C33H35Cl2N3O4 |
| Molar Mass | 608.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wei-Chung Chiang, et al. High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. 2018 Aug 17;13(8):2247-2260. |
BRD1991
CAS: 2235468-02-5 F: C33H35Cl2N3O4 W: 608.55
BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of
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