BCL6 PROTAC 1_product_DataBase

Bioactivity	BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research[1].
Target	B-cell lymphoma 6, BCL6
Invitro	BCL6 PROTAC 1 (Compound 15) (0.0001-10 µM；1-72 h) 在 OCI-Ly1 细胞中，以剂量依赖性方式降解 B 细胞淋巴瘤 6 (BCL6)[1]。 Cell Viability Assay[1] Cell Line:
Name	BCL6 PROTAC 1
CAS	2257479-54-0
Formula	C45H52ClN9O12
Molar Mass	946.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. McCoull W, et al. Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141.

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