| Bioactivity | BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2 |
| Target | IC50: 2 nM (FAP), 49.0 μM (PREP), >100 μM (DPP-4) |
| In Vivo | BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner[1]. Animal Model: |
| Name | BR102910 |
| CAS | 2505339-54-6 |
| Formula | C18H14Cl2F2N4O2S |
| Molar Mass | 459.30 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Hui Jin Jung, et al. Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. Bioorg Med Chem Lett. 2021 Apr 1;37:127846. |
BR102910
CAS: 2505339-54-6 F: C18H14Cl2F2N4O2S W: 459.30
BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prol
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