S-23_product_DataBase

Bioactivity

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].

Target

Ki: 1.7 nM (Androgen receptor)

Invitro

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM[1].

In Vivo

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively[1]. Animal Model:

Name

S-23

CAS

1010396-29-8

Formula

C18H13ClF4N2O3

Molar Mass

416.75

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):38 [2]. Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598.

PeptideDB

S-23

CAS: 1010396-29-8 F: C18H13ClF4N2O3 W: 416.75