BMS-199264 hydrochloride_product_DataBase

Bioactivity	BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC50=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion[1].
Invitro	BMS-199264 hydrochloride (1 μM、3 μM、10 μM) 在 25 分钟全脑缺血后 30 分钟再灌注后以浓度依赖性方式增加挛缩发作时间并减少 LDH 释放[1]。BMS-199264 hydrochloride (3 μM) 对 ATP 合成酶或水解酶活性有不同的影响，分别为 0.23 μMATP/min/mg 和 0.18 μMATP/min/mg[1]。
Name	BMS-199264 hydrochloride
CAS	186180-83-6
Formula	C26H32Cl2N4O4S
Molar Mass	567.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Grover GJ, et al. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96.

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