| Bioactivity | AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50 = 1189 nM) and NPFF1R partial agonist (EC50 = 2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2]. |
| Target | NPFF2R/1R. |
| In Vivo | AC-099 hydrochloride (化合物 3; 30 mg/kg; i.p.; single) 完全减弱了 SNL (脊神经结扎) 诱导的大鼠超敏性[2]。 Animal Model: |
| Name | AC-099 hydrochloride |
| CAS | 849335-07-5 |
| Formula | C9H9Cl2F3N4 |
| Molar Mass | 301.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. [2]. Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. |
AC-099 hydrochloride
CAS: 849335-07-5 F: C9H9Cl2F3N4 W: 301.10
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50 = 1189 nM) and NPFF1R partial agonist (EC50 =
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