| Bioactivity | BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1]. | ||||||||||||
| Target | Ki: 25.8 nM (LFA-1) | ||||||||||||
| Name | BIRT 377 | ||||||||||||
| CAS | 213211-10-0 | ||||||||||||
| Formula | C18H15BrCl2N2O2 | ||||||||||||
| Molar Mass | 442.13 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177. |
BIRT 377
CAS: 213211-10-0 F: C18H15BrCl2N2O2 W: 442.13
BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICA
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