| Bioactivity | BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM)[1]. |
| Formula | C32H36N6O3 |
| Molar Mass | 552.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shlevkov E, et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience. 2021 Dec 18;25(1):103650. |