BIM 23042 TFA_product_DataBase

Bioactivity

BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release[1][2][3].

Name

BIM 23042 TFA

Sequence

{DNal}-Cys-Tyr-{DTrp}-Lys-Val-Cys-{Nal}-NH2 (Disulfide bridge:Cys2-Cys7)

Shortening

{DNal}-CY-{DTrp}-KVC-{Nal}-NH2 (Disulfide bridge:Cys2-Cys7)

Formula

C63H73N11O9S2.xC2HF3O2

Molar Mass

1192.45 (free base)

Appearance

固体

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Reference

[1]. R R Ryan, et al. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13;306(1-3):307-14. [2]. Santosh K Mishra, et al. A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. [3]. M Orbuch, et al. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol Pharmacol. 1993 Oct;44(4):841-50.

PeptideDB

BIM 23042 TFA

CAS: F: C63H73N11O9S2.xC2HF3O2 W: 1192.45 (free base)