| Bioactivity | BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM). BET-IN-14 has anti-cancer activity[1]. |
| Target | BET (IC50: 5.35 nM) |
| Invitro | BET-IN-14 (Compound 171) (72 h) 显示出对多种癌细胞系的抗肿瘤活性 (平均 IC50: 174.7 nM），尤其是在 MM.1S、Ty-82、MV-4-11 和 KG-1 细胞中[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | BET-IN-14 (化合物 171) (50 和 100 mg/kg，p.o.，qd) 抑制 MV-4-11 异种移植瘤小鼠中的肿瘤生长[1]。 Animal Model: |
| Name | BET-IN-14 |
| CAS | 2243669-93-2 |
| Formula | C30H37N7O2 |
| Molar Mass | 527.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Damaneh MS, et al. A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction. Invest New Drugs. 2020 Jun;38(3):700-713. |