| Bioactivity | BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1]. |
| Target | IC50: 0.15 ± 0.10 nM (eqBChE), 45.2 ± 45.0 nM (hBChE) |
| Name | BChE-IN-8 |
| CAS | 2653349-78-9 |
| Formula | C18H12BrN7O2 |
| Molar Mass | 438.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Q, Xiong B, Wang Y, Lyu W, Xing S, Chen Y, Liao Q, He S, Feng F, Liu W, Chen Y, Sun H. A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement. Eur J Med Chem. 2022 Jun 7;239:114510. |
BChE-IN-8
CAS: 2653349-78-9 F: C18H12BrN7O2 W: 438.24
BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50
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