| Bioactivity | AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research[1]. |
| Invitro | AChE/BChE-IN-12 (compound 10b) 与 AChE 的外周阴离子位点 (PAS) 和催化阴离子位点 (CAS) 残基相互作用[1]。 |
| Name | AChE/BChE-IN-12 |
| Formula | C23H21N3O6 |
| Molar Mass | 435.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sharma A, et al. Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase. ACS Omega. 2023 Mar 16;8(12):11161-11176. |