| Bioactivity | BChE-IN-29 (Compound 27a) is a BChE inhibitor (IC50: 0.078 μM and 0.74 μM for BChE and AChE respectively). BChE-IN-29 has anti-inflammatory activity and can be used for research of AD[1]. |
| Invitro | BChE-IN-29 (5 μM，24 小时) 可降低 SH-SY5Y 细胞 ROS 水平，表明化合物 具有抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BChE-IN-29 相关抗体: |
| In Vivo | BChE-IN-29 (5 mg/kg，腹腔注射) 缩短了小鼠到达平台的时间，表明东莨菪碱 (HY-N0296) 或 Aβ1-42 诱导的小鼠的认知能力得到改善[1 ]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C22H37N3O3S |
| Molar Mass | 423.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 7. |