| Bioactivity | BChE-IN-16 (compound 87) is a highly potent BChE inhibitor with an IC50 of 3.8 nM for hBChE. BChE-IN-16 has low cytotoxicity, potential CNS permeability, unique adaptability and can be used in Alzheimer's disease (AD) research. |
| Invitro | BChE-IN-16在IC50值大于10 μM时，对hAChE的抑制率为零[1]。BChE-IN-16对hBChE竞争性抑制，Ki 值为 4.04 nM[1]。BChE-IN-16对SH-SY5Y 细胞系具有细胞毒性，IC50 值为87.0 μM[1]。BChE-IN-16对HepG2 细胞系具有细胞毒性，IC50 值为76.0 μM[1]。 |
| Name | BChE-IN-16 |
| Formula | C28H32FNO2 |
| Molar Mass | 433.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pidany F, et al. Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation. Eur J Med Chem. 2023 Apr 5;252:115301. |