| Bioactivity | BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model[1][2]. |
| In Vivo | BCX-1898 (1, 10 mg/kg/天; 口服给药; 22 天) 以 10 mg/kg/天显示出对流感病毒的完全保护[2]。 BCX-1898 (0.01, 0.1 mg/kg/天; 鼻内给药; 20 天) 表现出完全保护作用 (10 个模型中有 10 存活)[2]。 Animal Model: |
| Name | BCX-1898 |
| CAS | 345267-14-3 |
| Formula | C17H32N4O3 |
| Molar Mass | 340.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. D F Smee, et al. Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities. Antimicrob Agents Chemother. 2001 Mar;45(3):743-8. [2]. Pooran Chand, et al. Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo. Bioorg Med Chem. 2005 Jun 2;13(12):4071-7. |