BAY-747_product_DataBase

Bioactivity	BAY-747 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model[1][2][3].
Target	Soluble guanylate cyclase (sGC)
Invitro	BAY-747 (100 nM) 与 WS 组合使用，可增强体外采集样 cLTP 模型中 AMPA 受体动力学[1] 。 Western Blot Analysis[1] Cell Line:
In Vivo	BAY-747 在研究的时间范围内显示出 0.6 ± 2.0 的脑血浆比，反映出 60% 的相对较高的脑渗透[1]。BAY-747（0.03-1.0 mg/kg，2 mL/kg；口服；在 24 小时间隔 OLT 中 T1 前 30 分钟）增强大鼠对象定位任务 (OLT) 模型中的长期记忆获取过程，并减弱 L -NAME 引起短期记忆障碍。 BAY-747 不影响海马体中含有 GluA1 的 AMPAR 动力学[1]。BAY-747（0.003-0.3 mg/kg；口服；单剂量）降低大鼠的血压，并且（3 mg/kg；口服；每天一次，持续 35 天）增加接受 l-NAME 处理的肾素的大鼠体重转基因模型[2]。BAY-747（150 mg/kg 食物；口服；16 周）提高雄性 mdx/mTRG2 小鼠的握力和跑步速度，表明骨骼肌功能得到改善[3]。 Animal Model:
Name	BAY-747
CAS	1609342-18-8
Formula	C22H26F2N4O2
Molar Mass	416.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Nelissen E, et al. The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms. Sci Rep. 2022 Mar 4;12(1):3589. [2]. Vakalopoulos A, et al. New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension. J Med Chem. 2023 Apr 11. [3]. Krishnan SM, et al. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy. Int J Mol Sci. 2021 Jul 27;22(15):8016.

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BAY-747

CAS: 1609342-18-8 F: C22H26F2N4O2 W: 416.46