BA-53038B_product_DataBase

Bioactivity

BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B[1].

Target

EC 50: 3.32 μM (HBV)

Invitro

BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM[1].BA-53038B has cytotoxicity with CC50 value of >100 μM[1].BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein[1].BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly[1].BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein[1].BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket[1].BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W)[1]. Western Blot Analysis[1] Cell Line:

Name

BA-53038B

CAS

2306195-65-1

Formula

C14H16ClNO

Molar Mass

249.74

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Zhang X, et al. Discovery of Novel Hepatitis B Virus Nucleocapsid Assembly Inhibitors. ACS Infect Dis. 2019 May 10;5(5):759-768.

PeptideDB

BA-53038B

CAS: 2306195-65-1 F: C14H16ClNO W: 249.74