| Bioactivity | Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2]. | ||||||||||||
| Invitro | Azoramide (0.01-100 µM; 0-24 h; Huh7 cells) regulates ER folding and secretion capacity without inducing ER stress[1].Azoramide (15 µM; 2-16 h; Huh7 cells) protects cells from induced ER stress. Azoramide counteracts Tunicamycin (Tm, HY-A0098)-induced ATF6LD-Cluc secretion and Tm-induced decrease of ASGR-Cluc secretion. Azoramide suppresses Tm-induced GRP78 and CHOP protein expression[1].Azoramide (15 µM; 2-16 h; Hepa 1-6 cells) alters ER calcium homeostasis and retains a greater fraction of Ca2+ in the ER[1].Azoramide (0-10 µM; 5 d) attenuates loss of PLA2G6D331Y/D331Y iPSC-derived midbrain DA neurons[2].Azoramide (10 µM; 5 d) reduces the increase in ROS and ameliorates the decline in mitochondrial membrane potential in PLA2G6D331Y/D331Y midbrain DA neurons[2].Azoramide (10 µM; 0-30 d) suppresses mitochondrial fragmentation in PLA2G6D331Y/D331Y midbrain DA neurons[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Azoramide | ||||||||||||
| CAS | 932986-18-0 | ||||||||||||
| Formula | C15H17ClN2OS | ||||||||||||
| Molar Mass | 308.83 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Azoramide
CAS: 932986-18-0 F: C15H17ClN2OS W: 308.83
Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves
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