| Bioactivity | Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1]. |
| Target | Kd: <0.1 μM (Axl, Mer, CSF1R) |
| Invitro | Axl/Mer-IN-1 (Compound 1) 抑制细胞 Axl 活性，通过 H1299 Elisa 法测得的IC50 为 <0.5 μM。Axl/Mer-IN-1 抑制细胞 CSF1R 活性，通过 THP-1 Elisa 法和 M-NFS-60 活力法测得的 IC50 分别为 <0.5 μM 和 <1.0 μM[1]。 |
| Name | Axl/Mer/CSF1R-IN-1 |
| CAS | 2394874-60-1 |
| Formula | C25H24F3N5O5 |
| Molar Mass | 531.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kiyean NAM, et al. Quinoline derivatives as inhibitors of axl/mer rtk and csf1r. Patent WO2019229251A1. |
Axl/Mer/CSF1R-IN-1
CAS: 2394874-60-1 F: C25H24F3N5O5 W: 531.48
Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of
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