| Bioactivity | Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1]. |
| In Vivo | Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1].Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h[1]. Animal Model: |
| Name | Autotaxin-IN-1 |
| CAS | 1619971-30-0 |
| Formula | C21H23N7O2 |
| Molar Mass | 405.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jones SB, et al. Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61. |
Autotaxin-IN-1
CAS: 1619971-30-0 F: C21H23N7O2 W: 405.45
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust P
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