Astin B_product_DataBase

Bioactivity	Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression[1].
Invitro	Astin B (0-60 μM, 12-48 h) 抑制 L-02 细胞的增殖[1]。Astin B (0-60 μM, 24 h) 诱导氧化应激和线粒体功能障碍，调节 Bcl-2/Bax 表达并增加 caspase-3 和 -9 活性[1]。Astin B (0-60 μM, 24 h) 在 L-02 细胞中诱导自噬以防止细胞凋亡[1]。Astin B 在肝细胞中引起氧化应激相关炎症，活性氧 (ROS) 水平升高、细胞内谷胱甘肽 (GSH) 含量降低以及 c-Jun 氨基末端激酶 (JNK) 磷酸化增强得到证实[1]。
In Vivo	Astin B (10 mg/kg，口服，每天一次，连续 7 天) 诱导小鼠肝损伤[1]。 Animal Model:
Name	Astin B
CAS	151201-76-2
Formula	C25H33Cl2N5O7
Molar Mass	586.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang L, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9.

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