| Bioactivity | Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation[1]. |
| Invitro | Asteltoxin (1-100 μg/ml) 抑制 CD63 阳性细胞外囊泡的产生，IC50 为 2.1 μg/ml，并且在 HT29 细胞中没有表现出明显的细胞毒性[1]。 Asteltoxin (1-10 μg/ml) 通过诱导 ATP 下调来激活 AMPK 通路并抑制 mTORC1 通路，激活溶酶体功能并抑制癌细胞 PC-3 分泌细胞外囊泡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Asteltoxin 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| CAS | 79663-49-3 |
| Formula | C23H30O7 |
| Molar Mass | 418.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mitani F,et al., Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function. Sci Rep. 2022 Apr 23;12(1):6674. |