| Bioactivity | Ascofuranone, a prenylphenol antibiotic, is a potent and selective trypanosome alternative oxidase (TAO) inhibitor. Ascofuranone has inhibitory activity against human dihydroorotate dehydrogenase (DHODH). Ascofuranone has diverse physiological activities, including antibiotic, hypolipidemic, anti-inflammatory, and anti-cancer[1][2]. |
| CAS | 38462-04-3 |
| Formula | C23H29ClO5 |
| Molar Mass | 420.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fukai Y, et al. Functional expression of the ascofuranone-sensitive Trypanosoma brucei brucei alternative oxidase in the cytoplasmic membrane of Escherichia coli. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Oct;124(2):141-8. [2]. Araki Y, et al. Heterologous production of ascofuranone and ilicicolin A in Aspergillus sojae. J Gen Appl Microbiol. 2022 Jun 20;68(1):10-16. |
Ascofuranone
CAS: 38462-04-3 F: C23H29ClO5 W: 420.93
Ascofuranone, a prenylphenol antibiotic, is a potent and selective trypanosome alternative oxidase (TAO) inhibitor. Asco
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