| Bioactivity | Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC50 >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC50 of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory[1][2][3]. |
| Target | IC50: >400 μM (cAMP-PDE), 9 μM (NFAT) |
| CAS | 2607-56-9 |
| Formula | C24H26O7 |
| Molar Mass | 426.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Okuyama T, et al., Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 1991 Jun;57(3):242-6. [2]. Thastrup O, et al., Inhibition of human platelet aggregation by dihydropyrano- and dihydrofuranocoumarins, a new class of cAMP-phosphodiesterase inhibitors. Biochem Pharmacol. 1985 Jun 15;34(12):2137-40. [3]. Nagasawa A, et al. Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway[J]. Natural Product Communications, 2014, 9(12): 1934578X1400901218. |