| Bioactivity | Apixaban-d3 (BMS-562247-01-d3)is the deuterium labeledApixaban(HY-50667)[1]. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[3]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| Name | Apixaban-d3 |
| CAS | 1131996-12-7 |
| Formula | C25H22D3N5O4 |
| Molar Mass | 462.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |
Apixaban-d3
CAS: 1131996-12-7 F: C25H22D3N5O4 W: 462.52
Apixaban-d3 (BMS-562247-01-d3)is the deuterium labeledApixaban(HY-50667). Apixaban (BMS-562247-01) is a highly selective
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