| Bioactivity | Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist[1]. |
| Invitro | Apimostinel (NRX-1074) modulates the NMDA receptor in a similar fashion to GLYX-13, but has a synthetic modification to one of the amino acids, conferring increased potency and oral bioavailability[1]. |
| In Vivo | In preclinical models the two compounds both appear to be highly efficacious across a number of CNS disorders[1]. |
| Name | Apimostinel |
| CAS | 1421866-48-9 |
| Formula | C25H37N5O6 |
| Molar Mass | 503.59 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Naurex's First Orally Active Molecule, NRX-1074, Demonstrates Statistically Significant Improvement in Depression Scores within 24 Hours in Phase 2 Study for Major Depressive Disorder. January 28, 2015. |