| Bioactivity | Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM[1]. |
| In Vivo | Antiviral agent 52 (10 mg/kg，腹腔注射) 优先分布在肝脏中，无明显肝毒性[1]。Antiviral agent 52 在 CD-1 小鼠体内的药代动力学分析[1]- |
| CAS | 101784-44-5 |
| Formula | C18H20Cl2N2 |
| Molar Mass | 335.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. He S, et al., Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. J Med Chem. 2016 Feb 11;59(3):841-53. |
Antiviral agent 52
CAS: 101784-44-5 F: C18H20Cl2N2 W: 335.27
Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hep
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