| Bioactivity | Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor. Antitumor agent-96 down-regulates the HR pathway by binding with MRE11 and suppressing its endonuclease functions. Antitumor agent-96 induces CM cells apoptosis[1]. |
| Target | MRE11 |
| Invitro | Antitumor agent-96 (Compound D34; 72 h) 在 CM-AS16 (IC50 = 2.9 ± 0.1 μM)、CRMM2 (IC50 = 0.7 ± 0.0 μM)、CM2005.1 (IC50 = 1.0 ± 0.1 μM) 和 CRMM1 (IC50 = 1.3 ± 0.3 μM) 的 CM 细胞中，与眼黑色素瘤、皮肤黑色素瘤和正常细胞相比，具有特殊的细胞毒性选择性[1]。Antitumor agent-96 (0.1-10 μM; 48 h) 诱导 CRMM1 细胞凋亡[1]。Antitumor agent-96 (0.3-10 μM; 48 h) 抑制 CRMM1 细胞迁移[1]。Antitumor agent-96 (0.3-10 μM; 48 h) 增加 CM 细胞 DNA 损伤积累，下调 HR 通路 MRN 复合物[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Antitumor agent-96 dihydrochloride (Compound D34 dihydrochloride; 10 and 20 mg/kg; i.p.; five times per week for 28 days) 在小鼠中有抗肿瘤效果[1]。 Animal Model: |
| Name | Antitumor agent-96 |
| Formula | C27H32N2O2 |
| Molar Mass | 416.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wei J, et al. Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma. Eur J Med Chem. 2023 Mar 15;250:115238. |