| Bioactivity | Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1]. |
| Invitro | Antitumor agent-38 (compound 9h) shows antiproliferative activity with GI50s of 0.66, 0.85, 0.76, 4.12, 3.67 µM for A549, MDA-MB-231, KB, KB-VIN, MCF-7 cells, respectively[1].Antitumor agent-38 (0.58, 1.74 µM; 24 h) induces cell cycle arrest at the late S and G2/M phase[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | Antitumor agent-38 |
| CAS | 2744193-34-6 |
| Formula | C22H24N2O4 |
| Molar Mass | 380.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xie L,et al. Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents. ACS Med Chem Lett. 2021; 12(12):1948-1954. |
Antitumor agent-38
CAS: 2744193-34-6 F: C22H24N2O4 W: 380.44
Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. A
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