| Bioactivity | Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B). Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC50 of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1[1]. |
| Formula | C34H41N9O |
| Molar Mass | 591.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bouzian Y, et al., Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma. Bioorg Chem. 2024 Jul 6;151:107597. |