| Bioactivity | Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A and SRC with IC50 of 6-50 nM. Antiproliferative agent-54 inhibits proliferation of several cancer cell, inhibits HUVEC and HepG2 with EC50 of 34 and 38 nM. Antiproliferative agent-54 exhibits good pharmacokinetic characteristics in rats[1]. |
| Target | IC50: 6 nM (ABL WT); 10 nM (B-RAFV600E); 15 nM (EGFR WT); 22 nM (HCK); 37 nM (LYN A); 40 nM (c-SRC); 44 nM (YES); 46 nM (ABLG250E); 50 nM (PDGFRA) |
| CAS | 1240322-54-6 |
| Formula | C29H25F3N6O3 |
| Molar Mass | 562.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Daydé-Cazals B, et al., Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors. J Med Chem. 2016 Apr 28;59(8):3886-905. |
Antiproliferative agent-54
CAS: 1240322-54-6 F: C29H25F3N6O3 W: 562.54
Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A
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