| Bioactivity | Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS[1]. |
| Invitro | Antiproliferative agent-49 (0.09 μM，24 h) 将 HepG-2 细胞周期阻滞于 G1/S 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antiproliferative agent-49 相关抗体: |
| Formula | C22H18N2O2S |
| Molar Mass | 374.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Serag MI, et al. New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study. Sci Rep. 2024 Mar 5;14(1):5474. |
Antiproliferative agent-49
CAS: F: C22H18N2O2S W: 374.46
Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is
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