Antiproliferative agent-18_product_DataBase

Bioactivity	Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity[1].
Target	Bacteria, Fungi
Invitro	Antiproliferative agent-18 (Compound 5k) (200 µg/ /8 mm disc; 24 h for bacteria, 48 h for fungi) 显示中等抑菌活性 (生长抑制区 14-17 毫米)，对酵母样致病真菌 Candida albicans 有中等活性 (生长抑制区 17 毫米)[1]。Antiproliferative agent-18 (0.1-100 μM; 48 h) 对人前列腺癌 (PC-3)、大肠癌 (HCT-116)、肝细胞癌 (HepG-2)、上皮样宫颈癌 (HeLa) 和乳腺乳腺癌 (MCF-7) 细胞系具有抗增殖活性[1]。Antiproliferative agent-18 在 SIRT1 酶的活性位点上占据了 NAD 辅因子和组蛋白脱乙酰酶抑制剂 EX527 的位置[1]。 Cell Proliferation Assay[1] Cell Line:
Name	Antiproliferative agent-18
Formula	C26H27FN2OS
Molar Mass	434.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Warda ET, et al. Synthesis and in vitro antibacterial, antifungal, anti-proliferative activities of novel adamantane-containing thiazole compounds. Sci Rep. 2022 Dec 6;12(1):21058.

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