| Bioactivity | Antimycobacterial agent-6 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis (Mtb)，targeting to both wild-type and fluoroquinolone-resistant Mtb strains. Antimycobacterial agent-6 inhibits Mtb DprE1-C387S mutant with MIC90s of 0.9 μM (H37Rv)，0.9 μM (MoxR)，0.5 μM (DprE1-P116S)，respectively[1]. |
| Target | Wild-type and fluoroquinolone-resistant Mtb |
| Name | Antimycobacterial agent-6 |
| Formula | C20H15F6N3O4 |
| Molar Mass | 475.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dube PS, et al. Quinolone analogues of benzothiazinone: Synthesis, antitubercular structure-activity relationship and ADME profiling. Eur J Med Chem. 2023 Oct 5;258:115539. |
Antimycobacterial agent-6
CAS: F: C20H15F6N3O4 W: 475.34
Antimycobacterial agent-6 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis (Mtb)，targeting to both wil
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