| Bioactivity | Antimalarial agent 38 (Compound 1) exhibits activity against antiplasmodial, which inhibits Plasmodium falciparum D6 strain, chloroquine-sensitive Thai strain and chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model[1]. |
| CAS | 123580-46-1 |
| Formula | C36H40N2O12 |
| Molar Mass | 692.71 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Auffret G, et al., Synthesis and antimalarial evaluation of a series of piperazinyl flavones. Bioorg Med Chem Lett. 2007 Feb 15;17(4):959-63. |
Antimalarial agent 38
CAS: 123580-46-1 F: C36H40N2O12 W: 692.71
Antimalarial agent 38 (Compound 1) exhibits activity against antiplasmodial, which inhibits Plasmodium falciparum D6 str
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