Antimalarial agent 26_product_DataBase

Bioactivity	Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo[1].
Invitro	Antimalarial agent 26 (compound 11) 抑制 P. falciparum 的 IC50 为 2.7 μM，而对哺乳动物细胞的 CC50 分别为 440.9 μM (HepG2) 和 1336 μM (Vero)[1]。Antimalarial agent 26 (1000-15.62 μM；2 小时) 在浓度为 250 至 15.6 μM 时显示溶血活性低于 40%[1]。
In Vivo	Antimalarial agent 26 (compound 11) (30 mg/kg；口服；每天一次，连续 4 天) 在雌性白化病瑞士小鼠中显示出抗疟活性[1]。Antimalarial agent 26 (300 mg/kg；口服；单次剂量) 在雌性小鼠导致肝细胞损伤的病理损伤[1]。 Animal Model:
Name	Antimalarial agent 26
CAS	2299199-56-5
Formula	C20H22N4O3
Molar Mass	366.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Costa Souza RM, et al. Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control. Eur J Med Chem. 2023 Jul 5;255:115400.

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