| Bioactivity | ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research[1]. |
| Invitro | ARN14494 (1-10 μM) 对小鼠原代星形胶质细胞SPT活性的抑制作用呈浓度依赖性[1]。ARN14494 (10 μM, 24 h) 降低Aβ1-42诱导的脑皮层星形胶质细胞神经酰胺和二氢神经酰胺水平[1]。ARN14494 (10 μM, 0-24 h) 抑制原代星形胶质细胞培养中寡聚 Aβ 诱导的促炎分子(包括 NO、TNF-α、IL1β、TGF1β、促炎酶INOS和COX-2) 的产生[1]。ARN14494 对皮质神经元 Aβ 神经毒性和 caspase-3 激活的影响[1]。 |
| Name | ARN14494 |
| CAS | 1037837-27-6 |
| Formula | C24H32N4O3 |
| Molar Mass | 424.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. De Vita T, et al. Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury. ACS Chem Neurosci. 2019 Mar 20;10(3):1627-1635. |