| Bioactivity | Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley. |
| Invitro | Antileishmanial agent-17 (compound 14b) 抑制叶酸途径，对叶酸的抑制率为 82% 和 91%，对亚叶酸的抑制率为 88% 和 91%，分别为 20 μM 和 100 μM[1]。Antileishmanial agent-17 对非洲绿猴肾细胞 (VERO 细胞) 表现出微弱的细胞毒性，CC50 为 244.3 μM[1]。 |
| Name | Antileishmanial agent-17 |
| Formula | C27H37N5O5 |
| Molar Mass | 511.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hassan NW, et al. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies. Eur J Med Chem. 2023 May 5;253:115333. |