Antifungal agent 51_product_DataBase

Bioactivity	Antifungal agent 51 (5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity[1].
Invitro	Antifungal agent 51 具有很强的抗真菌活性，尤其是对白色念珠菌 FDC 151、近平滑念珠菌 ATCC 22019 和热带念珠菌 FDC 138，具有 MIC 值小于 0.063 μg/mL，对白色念珠菌 CMRC 19 和光滑念珠菌FDC 192，MIC 值为 0.125 μg/mL，对白色念珠菌 CMRC 192，MIC 值为 0.25 μg/mL，对抗光滑念珠菌 CMRC 89，MIC 值为 1 μg/mL[1]。Antifungal agent 51（6.25、12.5、25 μg/mL；48 小时）在 BEAS-2B 和 HepG2 细胞中即使在 25 μg/mL 的相对高浓度下也会部分影响细胞系的活力[1]。 Cell Viability Assay[1] Cell Line:
Name	Antifungal agent 51
CAS	2896209-47-3
Formula	C18H16FN5OS
Molar Mass	369.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ghobadi E, et al. Design, synthesis and biological activity of hybrid antifungals derived from fluconazole and mebendazole. Eur J Med Chem. 2023 Mar 5;249:115146.

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