| Bioactivity | Anticancer agent 94 is a 4-Hydroxycoumarin derivative. Anticancer agent 94 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors[1]. |
| Invitro | Anticancer agent 94 (compound 4i) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~ 40%[1].Anticancer agent 94 (15 μM; 24-72 h) significantly inhibits A549 cell migration[1].Anticancer agent 94 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers[1]. Western Blot Analysis[1] Cell Line: |
| Name | Anticancer agent 94 |
| Formula | C22H15NO4 |
| Molar Mass | 357.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhou R, et, al. Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility. Sci Rep. 2022 Dec 14;12(1):21635. |