Anticancer agent 220_product_DataBase

Bioactivity	Anticancer agent 220 is a chromanone derivative with anticancer effects. Anticancer agent 220 shows highly potent activity in the colon cancer cell lines. Anticancer agent 220 induces apoptosis and cell cycle arrest in cells[1].
Invitro	Anticancer agent 220 (compound 14C) 在 HCT-116 细胞中表现出细胞毒性，IC50 为 53.3 µg/mL。Anticancer agent 220 诱导 HCT-116 细胞中的 DNA 碎片，下调 CDK4 以及抗凋亡基因 Bcl-2 的表达水平，上调促凋亡基因 P53 和 Bax 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 220 相关抗体:
Formula	C22H19Cl3N2O6
Molar Mass	513.76
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Heba M Abo-Salem, et al. Synthesis, bioactivity assessment, molecular docking and ADMET studies of new chromone congeners exhibiting potent anticancer activity. Sci Rep. 2024 Apr 26;14(1):9636.

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