Bioactivity | 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity[1]. |
Sequence | 5-FAM-Thr-Glu-Gly-Glu-Ala-Arg-Gly-Ser-Val-Ile-Leu-Leu-{Lys(5-TAMRA)}-Lys-NH2 |
Shortening | 5-FAM-TEGEARGSVILL-{Lys(5-TAMRA)}-K-NH2 |
Formula | C111H148N22O30 |
Molar Mass | 2270.49 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Zhao P, et al. Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis. ACS Pharmacol Transl Sci. 2022 Jun 22;5(7):458-467. |