Anticancer agent 164

CAS: 2235393-30-1 F: C21H23F3N8O2S2 W: 540.58

CML-IN-1 (compound 7) is a potent anticancer agent. CML-IN-1 displays very good induced-apoptosis effect for human chron

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Bioactivity	CML-IN-1 (compound 7) is a potent anticancer agent. CML-IN-1 displays very good induced-apoptosis effect for human chronic myeloid leukemia (CML) cell line K562. CML-IN-1 exerts its effect via a significantly reduced protein phosphorylation of PI3K/Akt signal pathway. CML-IN-1 (compound 4) also inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer[1][2].
Invitro	CML-IN-1 (compound 7) 在细胞检测中表现出最低的细胞毒性和更好的生物活性（K562，IC50：0.038 μM）[1]。CML-IN-1 (compound 4) 显着抑制 HCT116 细胞增殖，48 小时后的 IC50 值分别为 8.04 ± 0.94 µM，72 小时后的 IC50 值分别为 5.52 ± 0.42 µM[2]。CML-IN-1 (compound 4) 以剂量依赖性方式抑制 HCT116 细胞的集落形成、迁移和侵袭，并诱导细胞凋亡并将细胞周期阻滞在 G2/M 期[2]。CML-IN-1 (compound 4) 抑制 HCT116 细胞中 MEK/ERK 信号传导的激活[2]。 0 --> Anticancer agent 164 相关抗体:
Name	Anticancer agent 164
CAS	2235393-30-1
Formula	C21H23F3N8O2S2
Molar Mass	540.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li W, et al. Design and synthesis of novel 1-phenyl-3-(5-(pyrimidin-4-ylthio)-1,3,4-thiadiazol- 2-yl)urea derivatives with potent anti-CML activity throughout PI3K/AKT signaling pathway. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1831-1835. [2]. Li W, et al. A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer. Acta Pharm. 2023 Sep 14;73(3):489-502.