| Bioactivity | Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC50=5.0 μM[1]. |
| Invitro | M109S (0.1-10000 nM, 24 ~ 48 h)对Bax和Bak诱导的细胞凋亡均有抑制作用[1]。M109S (0-10μM, 4 h)抑制Staurosporine (HY-15141 STS)诱导的MEF细胞凋亡[1]。M109S (0-10μM, 24 h)抑制依托泊苷(HY-13629 Etoposide)诱导的Neuro2a细胞凋亡[1]。M109S (500 nM, 24 h)抑制Obatoclax(HY-10969A)诱导的ARPE19细胞凋亡[1]。M109S (500 nM, 48 h)抑制构象变化(N端暴露) [1]。M109S (500 nM, 48 h)抑制Bax的线粒体易位[1]。M109S(1.0 μM, 4h)降低线粒体耗氧量和活性氧，而M109S(0.1-1 mM)增加糖酵解[1]。 0 --> Anticancer agent 160 相关抗体: Apoptosis Analysis[1] Cell Line: |
| In Vivo | M109S(10mg/kg灌胃, 48 h 内注射三次)可保护视网膜免受强光诱导的光感受器死亡[1]。M109S(腹腔注射, 1mg /kg，静脉注射, 5mg /kg，或口服灌胃, 10mg /kg))是一种穿透血脑/视网膜屏障的口服生物活性细胞死亡抑制剂[1]。 Animal Model: |
| Name | Anticancer agent 160 |
| Formula | C28H29NO6 |
| Molar Mass | 475.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Singh CP, et al. Semisynthesis of Novel Dispiro-pyrrolizidino/thiopyrrolizidino-oxindolo/indanedione Natural Product Hybrids of Parthenin Followed by Their Cytotoxicity Evaluation. ACS Omega. 2023 Sep 14;8(38):35283-35294. |