Anticancer agent 105_product_DataBase

Bioactivity	Anticancer agent 105 is a compound based on thienopyrimidine scaffold, with with good safety and anticancer properties. Anticancer agent 105 shows selective toxicity towards melanoma cancer, and induces apoptosis. And Anticancer agent 105 significantly inhibits the metastatic nodules, even in pulmonary metastatic melanoma mouse model[1].
Invitro	Anticancer agent 105 (compound 9cb) 显示出对癌细胞的选择性，同时它抑制癌细胞（B16–F10 黑色素瘤）和正常非癌性成纤维细胞 (MEF NF2) 的 IC50 分别为 2.41 μM 和 >100 μM[1]。Anticancer agent 105 (0.5-10 μM; 24 h) 显示出对癌细胞的毒性，并且 (5-20 μM; 48 h) 在 B16-F10 细胞中诱导细胞凋亡和坏死[1]。 Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Anticancer agent 105 (compound 9cb) (9-9.5 mg/kg，每 3 天一次，持续 22 天；ip) 抑制携带 B16-F10 黑色素瘤的 C57BL/6 小鼠的转移性结节[1]。 Animal Model:
Name	Anticancer agent 105
Formula	C25H24KN3O6S
Molar Mass	533.64
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rogova A, et al. Synthesis of thieno[3,2-e]pyrrolo[1,2-a]pyrimidine derivatives and their precursors containing 2-aminothiophenes fragments as anticancer agents for therapy of pulmonary metastatic melanoma. Eur J Med Chem. 2023 Jun 5;254:115325.

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