Anticancer agent 102_product_DataBase

Bioactivity	Anticancer agent 102 is a derivative of tetracaine. Anticancer agent 102 has anti-cancer activity. Anticancer agent 102 induces apoptosis[1].
Invitro	Anticancer agent 102 (compound 2s; 24 and 48 h) 具有抗肿瘤活性，对 Colo-205 和 HepG2 细胞的 IC50 值分别为 299.4 μM 和 62.9 μM[ 1].Anticancer agent 102 (25 µM 和 50 µM; 24 h) 下调了 Colo-205 细胞中凋亡蛋白 PI3K 和 FoXO3a 的表达水平，上调了 PTEN 和 FoXO1 的表达水平。Anticancer agent 102 (24 h) 上调 Bax 表达并诱导 HepG2 细胞系中的 caspase-3 依赖性细胞凋亡。 Cell Viability Assay[ 1] Cell Line:
Name	Anticancer agent 102
CAS	2914922-86-2
Formula	C20H19F6N3O
Molar Mass	431.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. M İhsan Han, et al. Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones. ACS Omega. 2023 Feb 28;8(10):9198-9211.

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