Antibacterial agent 138_product_DataBase

Bioactivity	Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls[1].
Invitro	Antibacterial agent 138 (化合物 e4) (0.063 μg/mL，24 h) 对 MRSA 和 MRSE 表现出优异的抑制作用[1]。Antibacterial agent 138 对多重耐药菌具有抗菌活性，MICs (0.063-32μg/mL) 比泰妙菌素低 16-64 倍[1]。Antibacterial agent 138 (60 μg/mL, 24 h) 在 HEPG2 和 HEK293 细胞中未显示出细胞毒性迹象[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	Antibacterial agent 138 (化合物 e4) (2.5-40 mg/kg，i.p.) 在全身多药耐药金黄色葡萄球菌感染小鼠模型中显示出抗菌活性[1]. Animal Model:
Name	Antibacterial agent 138
Formula	C34H52INO4S
Molar Mass	697.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yi Y, et al. Novel pyridinium cationic pleuromutilin analogues overcoming bacterial multidrug resistance. Eur J Med Chem. 2023 May 5;251:115269.

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