Anti-inflammatory agent 91_product_DataBase

Bioactivity	Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that may improve skin inflammation of psoriasis by inhibiting the NF-κB and STAT3 signaling pathways [1].
Invitro	Anti-inflammatory agent 91 (Compound 4o) (10-80 μM; 24 h) 对 HaCaT 细胞活力无显著影响[1]。Anti-inflammatory agent 91 (10-40 μM; 2 h) 在 LPS (1 μg/mL; 24 h; 24) 诱导的 RAW264.7 和 HaCaT 细胞中显著降低 NO (IC50= 19.5 μM)、TNF-α、IL-6 (RAW264.7) 和 IL-17A (HaCaT) 水平，具有抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anti-inflammatory agent 91 相关抗体:
In Vivo	Anti-inflammatory agent 91 (Compound 4o) (25-100 mg/kg; 局部涂抹，一天一次连续 5 天) 可通过抑制炎性细胞因子改善银屑病[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C23H16ClF2NO6S
Molar Mass	507.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhao X, et al. Discovery of novel chrysin derivatives as potential Anti-Psoriasis agents[J]. Bioorganic Chemistry, 2024, 150: 107599.

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