Anti-inflammatory agent 79

CAS: F: C21H17NO2 W: 315.37

Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which

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Bioactivity	Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body.[13][1].
Invitro	Anti-inflammatory agent 79 (2.5-10 μM; 24 h) 可浓度依赖性地阻断缺氧诱导的 HIF-1α 蛋白积累，减少炎症反应，抑制细胞侵袭性并促进人 RA 滑膜细胞系中 VHL 依赖性 HIF-1α 降解[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anti-inflammatory agent 79 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Anti-inflammatory agent 79 (30 mg/kg, 60 mg/kg; ip; 2 天 1 次, 共 16 天) 改善了佐剂诱导关节炎 (AIA) 大鼠模型中踝关节的病理损伤，减少了血管生成并减弱了炎症反应[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C21H17NO2
Molar Mass	315.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Cai L, et al. Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis. Eur J Med Chem. 2024 Apr 16;271:116417.

2-Keto-L-gulonic acid

PAR 4 (1-6) (human)