| Bioactivity | Anti-inflammatory agent 50 (compound a1) is a Fusidic acid derivative with anti-inflammatory effects. Anti-inflammatory agent 50 inhibits inflammatory factor NO, IL-6 and TNF-α. Anti-inflammatory agent 50 alleviates acute lung injury by regulating inflammatory mediators and suppressing the MAPK, NF-κB and NLRP3 inflammasome signaling pathways[1]. |
| Invitro | 在 LPS 诱导的 RAW264.7 细胞中，Anti-inflammatory agent 50 (compound a1) 抑制炎症因子 NO（IC50 为 3.26 μM）、IL-6（IC50） 1.85 μM）和 TNF-α（IC50 为 3.88 μM）。Anti-inflammatory agent 50 显着抑制某些免疫相关细胞毒性因子的表达，包括 COX-2 和诱导型一氧化氮合酶 (iNOS)[1]。 |
| In Vivo | Anti-inflammatory agent 50 (compound a1) 可以减轻 LPS 诱导的急性肺损伤（ALI）小鼠的肺部炎症以及 NO、IL-6、TNF-α、COX-2 和 iNOS。Anti-inflammatory agent 50 (compound a1) 通过下调 p38 MAPK、c-JNK 和 ERK 的磷酸化来抑制丝裂原激活蛋白激酶 (MAPK) 信号通路。 此外，Anti-inflammatory agent 50 还可抑制抑制性 NF-κB 抑制剂 α (IκBα) 的磷酸化，从而抑制 NF-κB 信号通路的激活[1]。 |
| Name | Anti-inflammatory agent 50 |
| Formula | C40H55N3O6 |
| Molar Mass | 673.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zheng Liu, et al. Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway. Eur J Med Chem. 2023 Aug 1;259:115697. |
Anti-inflammatory agent 50
CAS: F: C40H55N3O6 W: 673.88
Anti-inflammatory agent 50 (compound a1) is a Fusidic acid derivative with anti-inflammatory effects. Anti-inflammatory
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